Inadequately Explained Chronic Dry Eye Symptoms and Corneal Pain: New Insights and Concepts
نویسندگان
چکیده
We argue that inadequately explained chronic dry eye-like symptoms reflect corneal hypersensitivity to tear evaporation (evaporative hyperalgesia) and those associated with the spectrum of disorders currently labeled as dry eye disease are consequences of neuropathic disorders of the corneal trigeminal nociceptive pathways in which clinical manifestations are determined by the location and downstream effects of its dysfunctional elements.
منابع مشابه
Ocular neuropathic pain
As the biological alarm of impending or actual tissue damage, pain is essential for our survival. However, when it is initiated and/or sustained by dysfunctional elements in the nociceptive system, it is itself a disease known as neuropathic pain. While the critical nociceptive system provides a number of protective functions, it is unique in its central role of monitoring, preserving and resto...
متن کاملCorneal Mechanical Thresholds Negatively Associate With Dry Eye and Ocular Pain Symptoms
PURPOSE To examine associations between corneal mechanical thresholds and metrics of dry eye. METHODS This was a cross-sectional study of individuals seen in the Miami Veterans Affairs eye clinic. The evaluation consisted of questionnaires regarding dry eye symptoms and ocular pain, corneal mechanical detection and pain thresholds, and a comprehensive ocular surface examination. The main outc...
متن کاملEvidence that dry eye represents a chronic overlapping pain condition
Abstract Recent data suggest that corneal somatosensory dysfunction may be the underlying cause of severe dry eye symptoms in the absence of ocular surface pathology seen in a subset of patients diagnosed with “dry eye syndrome.” This subset of patients tends to demonstrate a unique constellation of symptoms that are persistent, more severe, and generally respond poorly to current dry eye thera...
متن کاملChronic dry eye symptoms after LASIK: parallels and lessons to be learned from other persistent post-operative pain disorders
Laser in-situ keratomileusis (LASIK) is a commonly performed surgical procedure used to correct refractive error. LASIK surgery involves cutting a corneal flap and ablating the stroma underneath, with known damage to corneal nerves. Despite this, the epidemiology of persistent pain and other long-term outcomes after LASIK surgery are not well understood. Available data suggest that approximatel...
متن کاملThe influence of neuropathy in dry eye symptoms: a review of corneal pain pathways and potential changes in nervous system
Dry eye disease is a troublesome ocular condition due to its multifactorial nature and the lack of association between signs and symptoms. This fact has led researchers to look beyond tear quality and stability, and hyperosmolarity and inflammation have lately been the focus of interest. Both are considered to have an impact on corneal nerve structure and function, although their role is still ...
متن کامل